Insomnia client foundation worldwide - chronic insomnia over 10 years

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Theory (2010-2013)

In recent years (2010-2013) fortunately progress has been made in the integration of electronic / physicist' / computational theory on one side, and physiological/medical theory on the other side.

The description in books is found to be more integral than in scientific articles, that are often biased to one of both sides.

Without claiming it to be the best and the whole true, the interested might enjoy the following list of 8 books on mainly neuro-electric circuitry (PDF - click)

Theory (elementary and pre-2010)

The-MUST-KNOW-essence

 

There is an active sleep state, NREM (non-REM), with the delicious SWS Slow Wave Sleep), like 'being in coma', that 'fights' again a different state: the 'wake state'. The mechanisme of letting one state win over the other is designed by our Creator - to the bad luchk of insomniacs this 'sleep-state-switch' is very complicated and has been fully described by mankind around 2010/2011 by Dr. C. Caper et.al.:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026325/

Read this forty page article and you know almost everything you need to know about sleep.

Having read above, one realises how stupid the question 'What is the cause of your insomnia?' Most people lack the intelligence to understand above neural mechanism ('a bridge too far') - so the question 'how come' is three bridges too far.

To short term, lighter insomnia there is often a series of obvious reasons: use the checklilst of a nomral sleep center. If you carry them about, but a year later you still have insomnia in a grave way, that wrecks you life, makes it impossible to you to be a good and capable parent, or detoriates your job performance and cv, jeopardizing your career, then it is time you come to US.

If a physician asks you 'Why don't you sleep?' immediately point out he/she is behing in her professipn, print out above sleeping mechanism and print out the:

International Classification of Sleep Disorders (PDF)

print that out as well, and show as well the sleep swich artikel as the Classification (pover 300 pages) to your physician. It may feel strange that you have to educate your physician, but be glad:
a) you provided a basis that your physician trusts as, as Foundation, and is prepared to co-operate
b) you made your physician a 'better human', he know doesn't have to 'shove off' serious chronic insomnia's but can take them seriously.

The COSTS of having long term insomnia are tremendous for the individual: poor job performance, less chance of a relationship (less to give), serious impairment of 'parental qualities' up to disablity to get a job it all. Besides, the 'quality of live' sleeping (e.g.) 2 hours a night makes the nights to a 'hellish experience and seriously impair overday joy and overday performance. Other organs (as muscles) do not get appropriate rest, hurt, and the whole organ has a clearly shorter life expectancy.

Further theory

When falling asleep, the central nervous system hands over control to a decentral nervous system. This should be a very natural and spontanous process. It is, unfortunately, not pre-programmed like a computer that after x minutes goes on standby, until it receives a stimulus (from mouse or keyboard), to 'wake up' to active mode. This all is regulated by the operating system, which is comparable to the central nervous system, but latter being far more complicated.

Without doubt it is possible to implant a chip in human brain that is programmed, and that can make your 'falling asleep' as reliable as a computer goes on standby.

Waking up is, with as well in computers as human beings, through a very clear stimulus to the senses that are officially asleep. So a very clear light, harsh sound, penetrating smell, clear push on the body wake you up.

Sleep has its phases, in between awakening and deep sleep. In the picture on the right you can see the difference: in deep sleep, the frequency of electronic activity (measured from outside, with electrodes) is 0,5 to 2 Hertz, so every half up to once in two seconds. But: electric activity is then very synchronized. In upper patterns you see larger frequencies and smaller amplitudes, which is conform the more random working of neurons during waking stage. This is ALL from the times measurement could only be done from outside, with electrodes.


When you are taking pills though, central nervous system is sedated and it is more difficult to wake up.

The best free 1-sheet on the web about the sleeping mechanism is this:

Until 2006, biology and physiology dominated the sleep research. Electronic measurement available was only EEG, from the outside of the sculp.

The way 'falling asleep' works is very complicated and is best described in the following thesis:

Physiology of falling asleep 2006

Apart from difficult to prove psychological methods, the only significant intervention to get sleep was until then: pharm.

Sleeping pills 'knock out' your central nervous system....so that also means:

  • too many pills can kill (but 99% of suicide attempts with sleeping pills fail, so it is not the best method)
  • knocking out central nervous systems can also, 'en masse' be used as chemical weapon, so there are some barriers to relieve the working of a chemical, because otherwise a 'Saddam Hussein' (not living anymore) could take advantage of a discovery and produce extra chemical weapons.

What was 'forgotten' for quite some time, is that in the nervous system 'neurons' are active: electrifiable cells that can pass on electricity as wel as chemicals.

Here is a good explanation of what a neurocell is: 3 page descriptiopn neuro cell

Thereafter, neuroscanning and neuro-imaging techniques 'exploded'. The very broad and multidisciplinary 'neuroscience' emerged, which is not anymore part of the medical field, but physics and electronical engineering. Multiple methods OTHER THAN PHARM emerged to cure insomnia. Unfortunately, most of them are patented.

Because of the inherent promise of neuroelectronics to insomnia, this foundation also took care of http://neuroelectronics.org. Another name for this field is 'Brain-Computer Interface', because wiht the after 2006 far better measurement of electrical happenings in the brain, electronical solutions could be thought out for the brain - but also were computer specialists inspired by the neuron to make computers more biological (the quantumcomputer, q-bits).

What sleeping clinics over the world use what scanners in order to apply a neuromodulation technique is currerntlye sorted out

An excellent starting point is the SleepResearchSociety, http://SleepResearchSociety.org. They publish a 'Sleep Guide' that may appear expensive, but is worth every penny.

In Europe, the European Sleep Research Society exists, http://www.esrs.eu/ They do not have a guide, like the Americans, but issue a 'Journal of Sleep'. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2869

Their papers are presented on this page:
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2869

They also present a list of sleepcentres that are approved by them: http://www.esrs.eu/membership-services/european-sleep-research-laboratories.html

To come directly to the heart of the matter, it is the 'brainpart' VPLo, Ventrolateral Preoptic Nucleus, that determines the quality of sleeo: from excellent to fragmented.

vlpo





ARTICLES

The most recent and relevant articles about electric infuence of functioning of the VPLo are:

  • http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1912.html (2012)

Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks

Central mechanisms of the sleep-wakefulness cycle control (2011)

sleep and Sleep Disturbances: biological basis and clinical implications (2007) ((2S b 9leep and is and clinical implications



BOOKS - LITERATURE LIST

1) 'Sleep Guide' American Sleep research society http://www.sleepresearchsociety.org/


2) 2005: 'Brain Control of Wakefulness and Sleep', Springer/Elsevier, Mircea Steriad and Robert W. McCarley, ISBN: 0-306-48714-4 - 2005


3) 2010: 'Flip-flop switch circuit sleep Saper' - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026325/


4) 2012: 'The Oxford Handbook of Sleep and Sleepdisorders' isbn 978-0-19-537620-3 - Charles M. Morin & Colin A. Espie


5) 2012: 'Principles and Practice of Sleep Medicine' - ExpertConsult - Elsevier- Meri H. Kryger, Thomas Roth, William C. Dement - isbn 978-1-4160-6645-3

MORE BOOKS

6) 'Development of the Nervous Systems' – Sanes, Reh, Harris, Academic Press Elsevier 2012, ISBN 978-0-12-374539-2

7) 'Principles of neural science' – Kandel, Schwartz, Jessell McGrawHill 2000 – ISBN 978-0-07-1120000-5

8) 'Handbook of 'Neural Activity Measurement' – Cambridge University press 2012 – ISBN 978-0-521-51622-8

9) 'Electromagnestism' Grant, Phillips – Wiley 2011 – ISBN 978-0-471-92712-9

10) 'Electromagnetic fields in biological systems', Lin, CRC Press 2012

11) 'Sleep and Anasthesia' – neural correlates in Theory and Experiment – Hutt – Springer 2011 – ISBN 078-1-4614-0172-8

12) 'Brain Control of Wakefulness and sleep ' Steriade and McCarley'- Kluwer 2005 – ISBN 0-306-48714-4

13) 'Brain Control of Wakefulness and sleep ' Steriade and McCarley'- Kluwer 2005 – ISBN 0-306-48714-4

14) 'Molecular Neuropharmacology' – Bestler, Hyman, Malenka – McGrawHill 2001 – no isbn

15) 'Electric and Magnetic fields' – Charles Oatley – Cambridge University Press 1976 – 0 521 29076 7


In a way, sleep medicine can be seen as 'approximate' solution. To have a 'precise' solution, the functioning of the VPLo must be 'measured', for example through brainmaps, like brainmaps.org
Another technique that is fast growing (also reflected in the number of publications about it in the first half of 2012) is: EEG-fMRI. After an EEG-fMRI, feedback training is done, like 10 years ago the bio-feedback emerged: one performs 'games' on a computer, and in order to perform well, one must 'play the game' in such a way that the correct brainwaves are practised. It is called 'fMRI vplo training' An example of such a centre is http://sitemaker.umich.edu/fmri.training.course/homebrainmaps.org

As briefly mentioned before, Amsterdam is looking for test persons for fMRI (you even get paid per houw): http://www.neurowiki.nl/?p=668 and Leuven (Belgium) as well https://perswww.kuleuven.be/~u0049922/contact.html

This is an example of an fMRI
First, MRI scanner:
MRI scanner

Then, examples of results:

So systematically speaking fMRI, for example in combination with EEG, is

3.1. method: exact determination and thereafter training. - like fMRI-EEG. AVAILABLE since 2012, for insomnia

Other methods come to mind as well, but are less developed yet:

3.2 exact determination and thereafter: electric inducement

EMS is an example of this, Electrical Muscle Stimulation - but likely not useful for insomnia.

DBS, Deep Brains Simulation, is another example: amongst others the VPLO is induced, but the DBS has so far only been worked out for Parkinsion and not for insomnia; it could happen.

http://www.ncbi.nlm.nih.gov/pubmed/19005057

3.3 exact determination and thereafter: implant

3.4 exact determination and thereafter: operation (theoretically speaking).


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